569-632 AD: Prophet Mohammed. “give infants a well chewed date”
1545: Boke of Chyldren: For crying at night: “...and if ye can gette any syrup of popye, geue it the chylde to licke...”
1845: Perry Davis Pain Killer (sugar, alcohol & opiates)
1917: Mixture of sugar and alcohol during circumcision
1960’s-1970s: Honey/glycerine on pacifiers
1981-1998: Nilstat used in the NICU to stop babies crying (12.5% sucrose)