"Sensory innervation of the human male prepuce: Meissner's corpuscles predominate"

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    • "Sensory innervation of the human male prepuce: Meissner's corpuscles predominate"

      Ich bin beim Stöbern auf Reddit über folgende, sehr interessante Studie gestolpert. Man hat dabei sowohl mittels immunhistochemischen und quantitativen Untersuchungen nach Mechano-Proteinen und Rezeptoren gesucht.

      Hier mal ein paar interessante Auszüge aus der Studie:

      García-Mesa et al. wrote:

      The prepuce samples were richly innervated by nerve fibers of various diameters that formed a dense network in the reticular dermis. These fibers formed perivascular plexuses, terminated as free nerve endings, and innervated sensory corpuscles of various morphotypes (Figure 1). Human male prepuce is richly innervated by nerve fibers of various diameters that form a dense network in the reticular dermis.

      García-Mesa et al. wrote:


      3.1 Meissner's corpuscles are the most common sensory corpuscles in the prepuce
      The sensory corpuscles located immediately beneath the epithelium were typical or ovoid Meissner's corpuscles. They displayed a notable tendency to aggregate in the cutaneous folds; their density was high in this region, while they were scarcely present in adjacent areas that were flat or depressed (Figure 2).


      The density and average index of Meissner's corpuscles in the analyzed samples were 8.3 ± 4.1 and 0.14 ± 0.001, respectively. The density of Meissner's corpuscles in participants aged <10 years, between 10 and 20 years, and >20 years was 3.0 ± 1.1, 11.3 ± 4.1, and 10.8 ± 3.7, respectively (Figure 5a). The average Meissner index was 0.02 ± 0.001 in the first decade of life, 0.21 ± 0.01 in the second decade, and 0.28 ± 0.01 in subsequent decades (Figure 5b). Significant differences (p < 0.001) were found in both parameters between participants in the pre-puberty group and those in the other two groups, while no significant differences in density or index of Meissner's corpuscles were found between the puberty and post-puberty groups.
      Wie man hier sieht, entwickelt sich die Empfindlichkeit der Vorhaut auch erst in der Pubertät. Morris hat mal irgendwo das Gegenteil behauptet, Quelle habe ich leider gerade nicht zur Hand.

      García-Mesa et al. wrote:


      3.2 Meissner's corpuscles of the prepuce show PIEZO2 expression
      In this study, intense PIEZO2 immunoreactivity was observed in the axons of Meissner's corpuscles (Figure 6a–d), as well as in scattered Merkel cells (Figure 6e,f). The pattern of axonal PIEZO2 immunostaining was punctate and did not show the entire axonal profile. Double immunolabeling was performed to confirm the localization of PIEZO2 within Meissner's corpuscles. It revealed that PIEZO2 did not co-localize with S100P (thus excluding glial localization) and matched the distribution of neuron-specific enolase well (thus confirming axonal localization, Figure 7).
      PIEZO2 ist ein Mechanoprotein, welches unter anderem auch in den Fingerspitzen vorkommt und beim Tastsinn eine große Rolle spielt.

      Der letzte Satz vom Fazit ist aber etwas widersprüchlich:

      García-Mesa et al. wrote:

      Although the effects of circumcision on penile sensitivity and sexual arousal are probably minor, the prepuce is the most sensitive area of the penis (Bossio et al., 2016), which is indicated by the rich innervation observed on microscopy in this study.
      Den wichtigen Teil habe ich mal fett hervor gehoben. Warum der Effekt auf die sexuelle Erregbarkeit und penile Sensitivität "wahrscheinlich minimal" sein soll, erschließt sich mir nicht wirklich.

      Es wird in naher Zukunft noch eine etwas ausführlichere Studie mit ähnlichem Fokus geben, die vermutlich auch die Frage nach der Anzahl der Nervenenden in der Vorhaut beantwortet.
      "The only thing necessary for the triumph of evil is for good men to do nothing"