Why Human Prepuce is a Valuable Resource in Science?

The foreskin is a unique mucocutaneous tissue that covers the glans penis... It is extensively vascularized and innervated..
Also, it contains free nerve endings, Meissner's corpuscles, and Pacinian corpuscles

TEM images of the foreskin of a human dyed with uranyl acetate and lead citrate. A. The photomicrograph showing different
layers of the epidermal skin with keratinocytes (K) dispersed among them, melanocytes (M) that rest on a folded basement membrane
(BM) with its lamina densa (LD) of the dermo-epidermal junction. Note the presence of minimal collagen fibrils (CF) in the graph's
corner in its dermis (D). (X2500). B. The photomicrograph showing a single keratinocyte (K) with an active nucleus (N) with prominent
nucleolus (nu). Keratinocytes terminate at the desmosomes (D), linking the cells (arrows) and forming wide cellular extensions. (X10000).
C. The photomicrograph showing a melanocyte with intercellular spaces (ICS) that are widened and reduced desmosomal content with
prominent active euochromatic nucleus (N) and nucleolus (nu). Note the presence of melanin granules (M) filling most cytoplasm and
prominent mitochondria (m). (X20000). D. The photomicrograph showing interstitial blood vessel showing lumen (Lu) surrounded by
endothelial cells (En) and basement membrane (Bm). Note, pericyte (P) and minimal collagen fibers (CF) in the interstitium (I)

ETHICAL APPROVED AND INFORMED CONSENT.
The Department of Plastic Surgery, College of Medicine,
King Khalid University of Abha, Saudi Arabia, generously
contributed tissue samples from the foreskin (from six boys
ages 1, 2, and 3 years, respectively)....
Before surgery, all patients signed a written informed consent form.